Fast-acting results, proven longevity, and an extensive international track record—what you need to know about this neuromodulator.
Letybo (letibotulinumtoxinA-wlbg) represents a significant advancement in botulinum toxin technology, offering patients a scientifically validated alternative for wrinkle reduction and facial rejuvenation. Health Canada-approved on June 14, 2022, for the treatment of moderate to severe glabellar lines, this South Korean-developed neuromodulator brings over a decade of international clinical experience to Canadian aesthetic practices [1][2]. With over 31 million treatments performed worldwide and ranking as the #1 neurotoxin in South Korea, Letybo has established itself as a globally trusted solution backed by robust clinical evidence [3][4][5].
Understanding Letybo’s Scientific Foundation
Letybo is manufactured by Hugel, Inc., a biopharmaceutical company recognized as a leader in aesthetic innovation, and is available in Canada through Hugel Canada Inc. [6][7]. The product contains a highly purified botulinum toxin type A with a 900 kDa molecular complex, produced through an enzyme-free purification process using protamine sulfate precipitation and double chromatography [8]. This advanced purification method removes nucleic acids and enzymes of animal origin, resulting in exceptional purity by eliminating bacterial side products [8].
The mechanism of action mirrors other type A botulinum toxins: Letybo temporarily inhibits acetylcholine release at the neuromuscular junction, reducing muscle activity and smoothing dynamic wrinkles [6][9]. What distinguishes Letybo is its focused diffusion pattern, offering practitioners enhanced precision when targeting specific muscle groups [6]. This reduced protein load may offer particular advantages for patients requiring long-term treatment, with clinical trials demonstrating that no patients developed neutralizing antibodies despite repeated exposure [8].
Clinical Evidence and Performance
The efficacy of Letybo has been demonstrated through rigorous Phase III clinical trials (BLESS I, II, and III) involving over 1,200 patients [8][10]. In these studies, composite responder rates at week 4 reached 46.5%, 48.8%, and 64.7% in the Letybo treatment groups compared to 0%, 1.9%, and 0% in placebo groups respectively [8][10]. These results demonstrate statistically significant and clinically meaningful improvements in glabellar line appearance [10][11].
Patients typically observe initial results within 2 to 3 days of treatment, with a significant number of patients in clinical trials reporting onset within 24 to 72 hours [8][12]. The duration of effect ranges from 3 to 4 months, with some patients experiencing results lasting up to 16 weeks [12][13]. Individual responses vary based on factors such as muscle strength, metabolism, and treatment area [6][14].
Safety Profile and Patient Experience
The safety profile of Letybo aligns closely with the established safety characteristics of botulinum toxin type A products [10][11]. In clinical trials, the most common adverse reaction was headache, occurring in approximately 2% of patients [15][8]. Local injection site reactions such as mild redness, swelling, and bruising typically resolve within a few days [6]. The product’s long history of safety—with millions of successful treatments globally—provides substantial real-world validation beyond clinical trials [16][12][17].
The treatment process itself is quick and relatively comfortable, with most sessions lasting 10 to 15 minutes [18]. Standard injection protocols for glabellar lines involve five injection points: one in the procerus muscle and two in each corrugator supercilii muscle [6]. Patients can generally return to normal activities immediately following treatment, with minimal to no recovery time required [18][19].
Why Sharief Aesthetics Offers Letybo
At Sharief Aesthetics, the decision to offer Letybo as a preferred neuromodulator reflects a commitment to providing patients with access to cutting-edge aesthetic technologies backed by robust clinical evidence. As a Health Canada-approved neuromodulator (DIN 02528134, 02528142), Letybo represents a significant milestone in aesthetic medicine [1][2][7]. Its approval in over 65 countries and extensive global track record demonstrate a level of international validation that inspires confidence [3][20].
The product’s high degree of purity, precise diffusion characteristics, and consistent clinical outcomes make it an excellent choice for both first-time patients and those experienced with neuromodulator treatments [6][19]. The focused area of activity allows for controlled, predictable results that maintain natural facial expression while effectively addressing dynamic wrinkles [6]. Physicians who have evaluated Letybo have noted its proven track record and favourable immunogenicity profile [8][16].
Treatment Areas and Applications
While Health Canada-approved specifically for glabellar lines, experienced practitioners utilize Letybo for various aesthetic applications depending on individual patient needs and anatomical considerations [6][19]. Common treatment areas include forehead lines, crow’s feet around the eyes, and other dynamic facial wrinkles that benefit from targeted muscle relaxation [9][19]. The precision formulation of Letybo makes it particularly well-suited for delicate work requiring controlled diffusion, allowing practitioners to achieve refined, natural-looking results [21][19].
What to Expect During Treatment
A comprehensive consultation precedes every Letybo treatment at Sharief Aesthetics, during which facial structure, expression patterns, and aesthetic goals are carefully assessed [21]. This personalized approach ensures that treatment plans are tailored to individual needs and desired outcomes [19]. During the procedure, small amounts of Letybo are injected using ultra-fine needles into targeted muscles [21].
Most patients report minimal discomfort, and the entire process is typically completed within 15 minutes [18]. Following treatment, patients receive detailed aftercare instructions to optimize results and minimize any potential side effects [21]. Results begin to emerge within 1 to 3 days, with full effects visible by approximately two weeks post-treatment [13][12]. The longevity of results typically ranges from 3 to 4 months, at which point repeat treatment can be scheduled to maintain the desired aesthetic outcome [6][18].
The Global Perspective
Letybo’s extensive international track record provides valuable insight into its long-term performance and patient satisfaction [18]. In South Korea, where aesthetic medicine represents one of the world’s most advanced and competitive markets, Letybo commands a significant market share and has maintained its position as a leading neurotoxin for years [5][22]. This market leadership in a highly sophisticated aesthetic landscape speaks to both provider confidence and patient satisfaction [23].
Physicians who have evaluated Letybo emphasize the value of its established international history [16]. This global experience, combined with rigorous Health Canada review, offers patients confidence in both the safety and efficacy of the product [1][8]. The fact that a high percentage of patients from initial trials chose to continue with additional treatment cycles demonstrates strong patient retention and satisfaction [8].
Making an Informed Choice
Choosing the right neuromodulator involves consideration of multiple factors, including clinical evidence, safety profile, onset of action, duration of effect, and practitioner expertise [14]. Letybo offers a compelling combination of these elements, backed by substantial clinical data and real-world experience across many countries [11][24][3]. The addition of Letybo to the Canadian aesthetic medicine landscape provides patients with more options and encourages continued innovation in the neuromodulator market [12].
At Sharief Aesthetics, the integration of Letybo into the treatment portfolio reflects an ongoing commitment to offering patients access to innovative, evidence-based aesthetic solutions that deliver consistent, natural-looking results. Whether seeking preventative treatment in earlier years or addressing established signs of aging, patients can feel confident in the quality and consistency of results that Letybo provides [21].
For patients seeking a neurotoxin with a rapid onset, a proven global safety record, and precise diffusion, Letybo’s scientific profile and extensive international experience make it a compelling choice.
Ready to see if Letybo is right for you? Contact Sharief Aesthetics today to schedule a personalized consultation with our expert providers.
Sources
[1] Health Canada Regulatory Decision Summary for Letybo – https://dhpp.hpfb-dgpsa.ca/review-documents/resource/RDS00962
[2] Health Canada Drug and Health Product Details – https://dhpp.hpfb-dgpsa.ca/dhpp/resource/101737
[3] BENEV and Hugel announce Letybo® is fully commercialized – https://news.valuranova.com/2025/03/25/benev-and-hugel-announce-letybo-is-fully-commercialized-in-the-u-s/
[4] Letybo—known as Botulax in South Korea—is currently the … – https://www.threads.com/@lonetreeaesthetics/post/DKCcFMlNDnO/video-letyboknown-as-botulax-in-south-koreais-currently-the-1-botulinum-toxin-in-korea
[5] Letybo Botulinum Toxin | Top Market Share in Korea, Ideal … – https://naissclinic.com/en/letybo.html
[6] All about Botox®, Xeomin®, Dysport®, Daxi®, Dermatox® … – https://iapam.com/starting-medical-practice-2/botox-xeomin-dysport-comparison
[7] Croma Aesthetics Canada Ltd. Receives Canadian Market Authorization – https://www.businesswire.com/news/home/20220623005812/en/Croma-Aesthetics-Canada-Ltd.-Receives-Canadian-Market-Authorization-for-Letybo-LetibotulinumtoxinA-for-Injection-for-the-Treatment-of-Glabellar-Lines
[8] PRODUCT MONOGRAPH INCLUDING PATIENT MEDICATION INFORMATION – https://pdf.hres.ca/dpd_pm/00066317.PDF
[9] What is Letybo? The Latest Neurotoxin for Wrinkles & More – https://evolvemedspa.com/blog/what-is-letybo-benefits-how-it-works-how-long-it-last-etc/
[10] Efficacy and Safety of Letibotulinumtoxin A in the Treatment … – https://pubmed.ncbi.nlm.nih.gov/35092418/
[11] Letybo is the Newest FDA-Approved Injectable Neurotoxin – https://www.realself.com/news/letybo-fda-approval
[12] Letybo – Sei Bella Med Spa – http://www.seibellamedspa.net/letybo
[13] Exploring the Differences Between Neuromodulators – https://dermmedica.ca/differences-between-neuromodulators-botox/
[14] Letybo is the Newest FDA-Approved Injectable Neurotoxin – https://marmurmedical.com/wp-content/uploads/2024/09/Letybo-is-the-Newest-FDA-Approved-Injectable-Neurotoxin-RealSelf-News-1.pdf
[15] Letybo in South Florida | GreeneMD Aesthetic Experts – https://www.drryangreene.com/letybo-in-south-florida/
[16] Letybo – Dr. Chernoff Plastic Surgery – https://drchernoff.com/non-surgical/neurotoxin-injections/letybo/
[17] Letybo – https://www.vixenaesthetics.com/injectables/letybo/
[18] BENEV Company, Inc. and Hugel Inc. are pleased to … – https://www.prnewswire.com/news-releases/benev-company-inc-and-hugel-inc-are-pleased-to-announce-that-letybo-letibotulinumtoxina-wlbg-is-now-fully-commercialized-in-the-us-marking-a-significant-milestone-in-the-neuromodulator-market-302409966.html
[19] Smooth, Natural-Looking Results with Letybo – https://medspaofdallas.com/dallas-letybo/
[20] Letybo 101: What It Is, How It Works, and Why It Matters – https://lantryaestheticscenter.com/letybo-101-what-it-is-how-it-works-and-why-it-matters/
[21] Botox’s biggest rival lands in the US — Leytbo said to be … – https://nypost.com/2025/03/12/lifestyle/botoxs-biggest-rival-lands-in-the-us-leytbo-said-to-be-faster-acting-and-up-to-30-cheaper/
[22] Diffusion Characteristics of LetibotulinumtoxinA, … – https://pmc.ncbi.nlm.nih.gov/articles/PMC12256374/
